Diabetes mellitus is a major metabolic disorder characterized by chronic hyperglycemia resulting from impaired insulin secretion, insulin action, or both. Due to the increasing prevalence of diabetes throughout the world, there has been a steady increase in the demand for safe and effective diabetic treatments that have no or negligible adverse reactions. As a result of this, many healthcare providers and researchers have turned their attention to traditional herbal medicines because of the bioactive compounds in many of these plants to treat diabetes. Our study will examine the ability of Jackfruit (Artocarpus heterophyllus), Papaya (Carica papaya) and Pentas (Pentas lanceolata) leaf ex-tracts to reduce blood glucose levels through in-vitro methods. Plant leaves are primary sources of secondary metabolites, including flavonoids, phenolic compounds, alkaloids, tannins and saponins, many of which are known to reduce glucose levels in diabetics. About this study, we have used jackfruit leaves that are well known for their antioxidant properties, papaya leaves that have a long history as agents of metabolic and immune modulation and pentas leaves that have sig-nificant medical applications. All of these plants have been used traditionally, but research has not yet validated their use in regulating blood glucose levels. The fresh plant leaves were washed and prepared (dried in the shade and pulverised), extracted, and a crude extract was obtained using the correct solvent. Crude extracts from plant leaves were assessed for in vitro antidiabetic activity using the standard enzyme inhibitors, α-amylase inhibition tests and α-glucosidase inhibition tests. Enzyme inhibition assays can determine how effective the crude extracts from plants are in delaying the absorption of digested carbohydrates and the release of glucose, thus aiding in the process of maintaining blood sugar levels within acceptable limits. We anticipate this research will help to clarify how certain medicinal plant leaf extracts can affect glucose metabolism, as well as give a basis for future research and investigation of these same herbal medicines for possible diabetes support. This can be viewed as validation of the age-old use of plants for health benefits. By validating traditional medicine practices through scientific methodology, we hope to open the door for more in-depth research into these natural resources and their potential for diabetes management.

Diabetes Mellitus, Hyperglycaemia, Jackfruit, Α-amylase, Papaya, Pentas, Α-glucosidase