The present study was conducted to evaluates the hypocholesterolemic and hypoglycemic effects of dietary Orange Albedo Powder (Citrus Aurantium L.) in the hypercholesterolemic albino rats, also to examine various oxidative stress-associated with some biochemical parameters. Thirty two male albino rats weighing 110 + 10 g were divided into four groups, the first group received the basal diet only and served as (negative control), the second group received the hypercholesterolemic diet and served as (positive control), the other two groups received hypercholesterolemic diet supplemented with 10%, 20% orange albedo powder respectively (OrAP) for six weeks spontanously. The obtained results revealed that the groups of rats which received diets supplemented with 10% and 20% OrAP were significantly decrease total lipid, total cholesterol, triglycerides, low density lipoprotein cholesterol, liver enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase), when compared with positive control, also kidney functions were significantly improved. Body weight gain and food intake were significantly decreased when compared with positive control. The results indicate that the orange albedo is a good source of natural fiber. It could use in obese people for body loss, also serves to improve blood picture and to reduce the blood glucose level in hypercholesterolemic rats.
| Published in | International Journal of Nutrition and Food Sciences (Volume 2, Issue 2) |
| DOI | 10.11648/j.ijnfs.20130202.17 |
| Page(s) | 70-76 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2013. Published by Science Publishing Group |
Orange Albedo Powder, Hypo-Cholesterolemic, Hypoglycemic Effects
| [1] | Baigent, C., Keech, A., Kearney, P.M., Blackwell, L., Buck, G., Pollicino, C., Kirby, A., Sourjina, T., Peto, R., Collins, R. and Simes, R. (2005). Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet, 366(9493):1267-78. |
| [2] | Gielen, S., Sandri, M., Schuler, G. and Teupser, D. (2009). Risk factor management: antiatherogenic therapies. Eur. J. Cardiovasc Prev. Rehabil., 16(Suppl. 2): S29-36. |
| [3] | Jones, P.H. (2008). Expert perspective: reducing cardiovascular risk in metabolic syndrome and Type 2 diabetes mellitus beyond low-density lipoprotein cholesterol lowering. Am. J. Cardiol., 102: 41L–47L. |
| [4] | Alsheikh-Ali, A.A. and Karas, R.H. (2009). The relationship of statins to rhabdomyolysis, malignancy, and hepatic toxicity: evidence from clinical trials. Curr Atheroscler Rep., 11: 100-104. |
| [5] | Joy, T.R. and Hegele, R.A. (2009). Narrative review: statin-related myopathy. Ann. Intern. Med., 150(12): 858 - 868. |
| [6] | Gil-Izquierdo, A., Gil, M.I. and Ferreres, F. (2002). Effect of processing techniques at industrial scale on orange juice antioxidant and beneficial health compounds. J. Agric. Food Chem., 50(18):5107-14. |
| [7] | Fernández-Ginés, J., Navarro, C., Sendra, E., Sayas, M., Fernández-López, J. and Pérez-Álvarez, J. (2001). Colourimetric characterization of meat emulsion containing albedo. Vol II. pp. 162-163. In: Proceedings of 47th International Congress of Meat Science and Technology. Cracovia, Poland. 304 p. |
| [8] | Pérez-Alvarez, J. A., Fernández-López, J., Sayas, E., Navarro, C. and Sendra, E. (2001). Effect of citrus fiber (albedo) incorporation in cooked pork sausages. In: Proceedings of International Food Technologists Annual Meeting. IFT Annual Meeting, New Orleans, Louisiana. 64 p. |
| [9] | Chau, C.F., Huang, Y.L. and Lin, C.Y. (2004). Investigation of the cholesterol-lowering action of insoluble fibre derived from the peel of Citrus sinensis L. cv. Liucheung. Food Chem., 87:361– 366. |
| [10] | Kang, H.J., Chawla, S.P., Jo, C., Kwon, J.H. and Byun, M.W. (2006). Studies on the development of functional powder from citrus peel. Bioresearch Technology, 97(4): 614-620. |
| [11] | Lario, Y., Sendra, E., García, J., Fuentes, C., Sayas, E., Fernández-López, J. and Pérez-Álvarez, J. (2004). Preparation of high dietary fiber powder from lemon juice by products. Innovative Food Science and Emerging Technologies, 5(1): 113-117. |
| [12] | Fernández-López, J., Fernández-Ginés, J., Aleson, L., Sendra, E., Sayas, E. and Pérez-Álvarez, J. (2004). Application of functional citrus by-products to meat products. Trends in Food Science and Technology 15(3-4): 176-185. |
| [13] | AOAC (2000). Method of analysis. Association of Official Agriculture Chemists. Washington D.C.USA, 17th ed. |
| [14] | Fukushima, M., Takayama, Y., Habaguchi, T. and Nakano, M. (1997). Comparative hypocholesterolemic effects of capybara (Hydrochoerus hydrochaeris dabbenei) oil, horse oil and sardine oil in cholesterolfed rats. Lipid, 32(4): 391-395. |
| [15] | Fossati, P. and Prencipe, L. (1982). The determination of triglyceride using enzymatic methods. Clin. Chem., 28: 2077-2080. |
| [16] | Reitman, S. and Frankel, S. (1957). A colourimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am. J. Clin. Path., 28(56): 56-62. |
| [17] | Rec, G. (1972). Optimised standard colorimetric methods. J. Clin. Chem. and Clin. Biochem.,10: 182. |
| [18] | Patton, C. J. and Crouch, S. R. (1977). Spectrophotmetric and kinetics investigations of the Berthelot reaction for the determination of ammonia. Analyti. Chem., 49: 464–469. |
| [19] | Faulkner, N.R. and King, J.W. (1976). Fundamental of clinical chemistry (2nd Trinder, P. (1969). Determination of blood glucose using an oxidation peroxidase system with a non carsinogenic chromogene. Ann. Clin. Biochem., 6: 24. |
| [20] | Henry, R. J. (1976). Clinical chemistry, Hoeber, New Yourk, 413. |
| [21] | Doumas, B.T., Peters, T. Jr. (1997). Serum and urine albumin: a progress report on their measurement and clinical significance. Clin. Chem. Acta, 258(1): 3-20. |
| [22] | International Committee for Standardization in Haematology. (1967). Recommendations for haemoglobinometry in human blood. Brit. J. Haemat., 13(4):71-75. |
| [23] | Natt, M. P. and Herrick, C.A. (1952). A new blood count diluent for counting erythrocytes and leukocytes of the chicken. Poult. Sci., 31: 735–738. |
| [24] | Campbell, T. W. (1995). Avian hematology and cytology, 2nd edition. Iowa State University Press, Ames, Iowa, 3–19. |
| [25] | Fisher, R.A. (1970). Statistical method for research workers Edinburgh ed. 14, Oliver and Boyed, p. 140. |
| [26] | Waller, R.A. and Duncan, D.B. (1969). Aboys rule for symmetric multiple comparison problem. An. State Assoc. J., 65: 1485-1503. |
| [27] | S.P.S.S. (1999). Statistical Package for the Social Sciences, version 10, SPSS, Inc., Chicago, Illinois. |
| [28] | Chau, C.F. and Huang, Y.L. (2003). Comparison of the chemical composition and physicochemical properties of different fibers prepared from the peel of Citrus sinensis L. Cv. Liucheng. Journal of Agricultural and Food Chemistry, 51(9): 2615-2618. |
| [29] | Milagro, F.I., Campion, J. and Martinez, J.A. (2006). Weight gain induced by high-fat feeding involves increased liver oxidative stress. Obesity (Silver Spring), 14:1118-1123. |
| [30] | Pratt, S.G. and Matthews, K. (2004). SuperFoods Rx: Fourteen Foods That Will Change Your Life. HarperCollins Publishers Inc., New York. 336 p. |
| [31] | Quazi, S., Yokogoshi, H., Yoshida, A. (1983). Effect of dietary fiber on hypercholesterolemia induced by dietary PCB or cholesterol in rats. The Journal of nutrition, 113(6):1109-18. |
| [32] | Gorinstein, S., Leontowicz, H., Leontowicz, M., Krzeminski, R., Gralak, M., Jastrzebski, Z., Park, Y.S., Jung, S.T., Kang, S.G. and Trakhtenberg, S. (2007). Effect of hesperidin and naringin on the plasma lipid profile and plasma antioxidant activity in rats fed a cholesterol-containing diet. Journal of the Science of Food and Agriculture, 87(7):1257-1262. |
| [33] | Marounek, M., Volek, Z., Synytsya, A and Copíková, J. (2007). Effect of Pectin and Amidated Pectin on Cholesterol Homeostasis and Cecal Metabolism in Rats Fed a High-Cholesterol Diet. Physiological Research, 56(4):433-42. |
| [34] | Akiyama, T., Tachibana, I., Shirohara, H., Watanabe, N. and Otsuki, M. (1996). High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidaemia in normal adult male Wistar rat. Diab. Res. Clin. Pract., 31(1-3): 27-35. |
| [35] | De Escalada Pla, M.F., Ponce, N.M., Stortz, C.A., Gerschenson, L.N. and Rojas, A.M. (2007). Composition and functional properties of enriched fiber products obtained from pumpkin (Cucurbita moschata Duchesne ex Poiret). Lebensmittel-Wissenschaft & Technologie, 40(7):1176-1185. |
| [36] | Jeon, S.M., Bok, S.H., Jang, M.K., Lee, M.K., Nam, K.T., Park, Y.B., Rhee, S.J. and Choi, M.S. (2001). Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. Life Sci., 69(24): 2855-66. |
| [37] | Hwang, J.T., Kwon, D.Y. and Yoon, S.H. (2009). AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols. N. Biotechnol., 26(1-2):17-22. |
| [38] | Zygmunt, K., Faubert, B., MacNeil, J. and Tsiani, E. (2010). Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK. Biochem. Biophys. Res. Commun., 398(2):178-83. |
| [39] | Mulvihill, E.E., Allister, E.M., Sutherland, B.G., Telford, D.E., Sawyez, C.G., Edwards, J.Y., Markle, J.M., Hegele, R.A. and Huff, M.W. (2009). Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes., 58(10): 2198-210. |
| [40] | Shah, M., Griffin, I.J., Lifschitz, C.H. and Abrams, S.A. (2003). Effect of orange and apple juices on iron absorption in children. Arch Pediatr Adolesc Med. 157(12):1232-15236. |
| [41] | Sudhahar, V., Kumar, S.A., Sudharsan, P.T., Varalakshmi, P. (2007). Protective effect of lupeol and its ester on cardiac abnormalities in experimental hypercholesterolemia. Vascul. Pharmacol. 46: 412-418. |
| [42] | Ali, S., Prasad, R., Naime, M., Zafar, H., Mahmood, A., Routray, I., Yalniz, M., Ibrahim, H.B., Sahin, K. (2011). Dried peel fraction of Citrus sinensis partially reverses pathological changes in rat model of liver cirrhosis. Mediterr. J. Nutr. Metab., 4:57–67. |
| [43] | Devi, K.P., Sreepriya, M., Balakrishna, K., Devaki, T. (2004). Protective effect of Premna tomentosa (L. Verbenaceae) extract on membrane-bound phosphatases and inorganic cations transport in acetaminophen-induced hepatotoxicity rats. Journal of Ethnopharmacology, 93: 371-375. |
| [44] | Devi, K.P., Sreepriya, M., Balakrishna, K., Devaki, T. (2005). Protective effect of Premna tomentosa extract (L. verbanacae) on acetaminophen-induced mitochondrial dysfunction in rats. Molecular and Cellular Biochemistry, 272(1-2): 171-177. |
| [45] | Özbek, H., Bayram, İ., Cengiz, N., Uğraş, S. (2005). Evaluation of Foeniculum vulgare compunds of Lethal Dose Levels and Hepatoprotective Effects.Turkish Pharmacological Society 18th National Pharmacology Congress, September, Izmir- Turkey, S40. |
| [46] | Karaca, M., İlhanb, F., Altana, H., Himc, A., Tütüncüa, M. and Özbekd H. (2005). Evaluation of hepatoprotective activity of Bergamot orange in rats. Eastern J. of Med. 10(1-2): 1- 4. |
| [47] | [Younes, H., Garleb, K.A., Behr, S.R., Demigne´, C., Remesy, C. (1998). Dietary fiber stimulates the extrarenal route of nitrogen excretion in partially nephrectomized rats . J. Nutr. Biochem., 9: 613- 620. |
| [48] | Jemai, H., Bouaziz, M., Fki, I., El Feki, A. and Sayadi, S. (2008). Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves. Chemicobiological Interactions, 176(2-3): 88-98. |
APA Style
M. M. H. Osfor, A. Hegazy, Maha Abd El-moaty, Mohammad A. Elmadbouly, A. M. R. Afify, et al. (2013). Hypo-Cholesterolemic and Hypoglycemic Effects of Orange Albedo Powder (Citrus Aurantium L.) on Male Albino Rats. International Journal of Nutrition and Food Sciences, 2(2), 70-76. https://doi.org/10.11648/j.ijnfs.20130202.17
ACS Style
M. M. H. Osfor; A. Hegazy; Maha Abd El-moaty; Mohammad A. Elmadbouly; A. M. R. Afify, et al. Hypo-Cholesterolemic and Hypoglycemic Effects of Orange Albedo Powder (Citrus Aurantium L.) on Male Albino Rats. Int. J. Nutr. Food Sci. 2013, 2(2), 70-76. doi: 10.11648/j.ijnfs.20130202.17
AMA Style
M. M. H. Osfor, A. Hegazy, Maha Abd El-moaty, Mohammad A. Elmadbouly, A. M. R. Afify, et al. Hypo-Cholesterolemic and Hypoglycemic Effects of Orange Albedo Powder (Citrus Aurantium L.) on Male Albino Rats. Int J Nutr Food Sci. 2013;2(2):70-76. doi: 10.11648/j.ijnfs.20130202.17
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Download@article{10.11648/j.ijnfs.20130202.17,
author = {M. M. H. Osfor and A. Hegazy and Maha Abd El-moaty and Mohammad A. Elmadbouly and A. M. R. Afify and Amr S. M. Elbahnasawy},
title = {Hypo-Cholesterolemic and Hypoglycemic Effects of Orange Albedo Powder (Citrus Aurantium L.) on Male Albino Rats},
journal = {International Journal of Nutrition and Food Sciences},
volume = {2},
number = {2},
pages = {70-76},
doi = {10.11648/j.ijnfs.20130202.17},
url = {https://doi.org/10.11648/j.ijnfs.20130202.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20130202.17},
abstract = {The present study was conducted to evaluates the hypocholesterolemic and hypoglycemic effects of dietary Orange Albedo Powder (Citrus Aurantium L.) in the hypercholesterolemic albino rats, also to examine various oxidative stress-associated with some biochemical parameters. Thirty two male albino rats weighing 110 + 10 g were divided into four groups, the first group received the basal diet only and served as (negative control), the second group received the hypercholesterolemic diet and served as (positive control), the other two groups received hypercholesterolemic diet supplemented with 10%, 20% orange albedo powder respectively (OrAP) for six weeks spontanously. The obtained results revealed that the groups of rats which received diets supplemented with 10% and 20% OrAP were significantly decrease total lipid, total cholesterol, triglycerides, low density lipoprotein cholesterol, liver enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase), when compared with positive control, also kidney functions were significantly improved. Body weight gain and food intake were significantly decreased when compared with positive control. The results indicate that the orange albedo is a good source of natural fiber. It could use in obese people for body loss, also serves to improve blood picture and to reduce the blood glucose level in hypercholesterolemic rats.},
year = {2013}
}
TY - JOUR T1 - Hypo-Cholesterolemic and Hypoglycemic Effects of Orange Albedo Powder (Citrus Aurantium L.) on Male Albino Rats AU - M. M. H. Osfor AU - A. Hegazy AU - Maha Abd El-moaty AU - Mohammad A. Elmadbouly AU - A. M. R. Afify AU - Amr S. M. Elbahnasawy Y1 - 2013/03/10 PY - 2013 N1 - https://doi.org/10.11648/j.ijnfs.20130202.17 DO - 10.11648/j.ijnfs.20130202.17 T2 - International Journal of Nutrition and Food Sciences JF - International Journal of Nutrition and Food Sciences JO - International Journal of Nutrition and Food Sciences SP - 70 EP - 76 PB - Science Publishing Group SN - 2327-2716 UR - https://doi.org/10.11648/j.ijnfs.20130202.17 AB - The present study was conducted to evaluates the hypocholesterolemic and hypoglycemic effects of dietary Orange Albedo Powder (Citrus Aurantium L.) in the hypercholesterolemic albino rats, also to examine various oxidative stress-associated with some biochemical parameters. Thirty two male albino rats weighing 110 + 10 g were divided into four groups, the first group received the basal diet only and served as (negative control), the second group received the hypercholesterolemic diet and served as (positive control), the other two groups received hypercholesterolemic diet supplemented with 10%, 20% orange albedo powder respectively (OrAP) for six weeks spontanously. The obtained results revealed that the groups of rats which received diets supplemented with 10% and 20% OrAP were significantly decrease total lipid, total cholesterol, triglycerides, low density lipoprotein cholesterol, liver enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase), when compared with positive control, also kidney functions were significantly improved. Body weight gain and food intake were significantly decreased when compared with positive control. The results indicate that the orange albedo is a good source of natural fiber. It could use in obese people for body loss, also serves to improve blood picture and to reduce the blood glucose level in hypercholesterolemic rats. VL - 2 IS - 2 ER -
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