Research Article | | Peer-Reviewed

Simultaneous Use of Medicinal Plants and Anticancer and Antihypertensive Drugs in Cancer Patients and Hypertensive Patients: A Case Study from Point G Hospital

Received: 23 September 2025     Accepted: 5 October 2025     Published: 28 October 2025
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Abstract

Cancer and hypertension are two of the leading causes of death worldwide. Earlier detection, treatment and better monitoring ensure effective management. The objective was to study the prevalence and identify the medicinal plants consumed by patients with cancer and high blood pressure. We conducted a descriptive cross-sectional study on the use of medicinal plants by patients undergoing chemotherapy and patients taking antihypertensive drugs, monitored respectively in the medical hematology-oncology department and the cardiology department of the Point-G University Hospital. The prevalence of medicinal plant use was 41.7% (n = 79) among patients undergoing chemotherapy and 59.2% (n = 61) among patients taking antihypertensive medication. Among these patients, women accounted for more than 62% in both cases. The main sources of information on the use of plants were traditional healers, followed by parents. A total of 37 plants species belonging to 22 families were recorded. The Fabaceae family was the most represented, followed by the Combretaceae family. The three most commonly used plants were Guiera senegalensis, Combretum micranthum and Saba senegalensis in patients undergoing chemotherapy and used in combination with carboplatin and ondansetron. Those of patients taking antihypertensive drugs were Euphorbia hirta, Combretum micranthum and Moringa oleifera, used in combination with Amlodipine, Furosemide and Bisoprolol. The risk of side effects was twice as high (relative risk = 2.07) in patients taking antihypertensive drugs who also consumed plants. The study revealed a high prevalence of medicinal plant use. There is a link between the occurrence of adverse effects and plant use.

Published in Pharmaceutical Science and Technology (Volume 9, Issue 2)
DOI 10.11648/j.pst.20250902.14
Page(s) 72-78
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2025. Published by Science Publishing Group

Keywords

Euphorbia Hirta, Guiera Senegalensis, Combretum Micranthum, Anticancer, Antihypertensive, Interaction, Mali

References
[1] Milan A, Puglisi E, Ferrari L, et al. Arterial hypertension and cancer. International Journal of Cancer 2014; 134: 2269-2277.
[2] Crosby D, Bhatia S, Brindle KM, et al. Early detection of cancer. Science 2022; 375: eaay9040.
[3] Chung R, Tyebally S, Chen D, et al. Hypertensive Cardiotoxicity in Cancer Treatment—Systematic Analysis of Adjunct, Conventional Chemotherapy, and Novel Therapies—Epidemiology, Incidence, and Pathophysiology. Journal of Clinical Medicine 2020; 9: 3346.
[4] World Health Organization. Hypertension. Available from:
[5] Traoré K, Bah S, Diawara SI, et al. Assessment of patients’ knowledge of their antihypertensive treatment at the mother and child hospital ‘‘Le Luxembourg’’, Mali. Journal of Drug Delivery and Therapeutics 2025; 15: 55-60.
[6] Ballo M, Somboro AM, Maiga M, et al. Evaluation of antimycobacterial activity of medicinal plants used by Malian traditional medicine practitioners to treat tuberculosis. International Journal of Biological and Chemical Sciences 2020; 14: 3145-3155.
[7] Bourgou S, Beji RS, Medini F, et al. Effet du solvant et de la méthode d’extraction sur la teneur en composés phénoliques et les potentialités antioxydantes d’Euphorbia helioscopia. Journal of New Sciences 2016; 28.
[8] Mouly S, Morgand M, Lopes A, et al. Interactions médicaments-aliments en médecine interne: quels messages pour le clinicien? La Revue de Médecine Interne 2015; 36: 530-539.
[9] Petitet F. Interactions pharmacocinétiques entre préparation à base de plantes et médicament: une revue de l’importance clinique. Phytothérapie 2012; 10: 170-182.
[10] Schieman C, Rudmik LR, Dixon E, et al. Complementary and alternative medicine use among general surgery, hepatobiliary surgery and surgical oncology patients. Can J Surg 2009; 52: 422-426.
[11] Makhlouf N, Ben Jedidia I, Ali MBH, et al. Les traitements traditionnels et les compléments alimentaires chez le patient atteint de cancer: État des lieux en Tunisie. Can J Hosp Pharm 77: e3586.
[12] McCrea CE, Pritchard ME. Concurrent herb-prescription medication use and health care provider disclosure among university students. Complement Ther Med 2011; 19: 32-36.
[13] Philibert C, Hoegy D, Philippe M, et al. Évaluation du recours aux médecines alternatives et complémentaires orales dans un service d’onco-hématologie pédiatrique. Bulletin du Cancer 2015; 102: 854-862.
[14] Bachev V, Yaneva I, Ignatov I. Research of the patients’ attitude in their use of plant products (traditional plant medicinal products, plant food supplements, teas) in Bulgaria. Journal of Medicine, Physiology and Biophysics 2018; 51: 1-9.
[15] Tarirai C, Viljoen AM, Hamman JH. Herb-drug pharmacokinetic interactions reviewed. Expert Opin Drug Metab Toxicol 2010; 6: 1515-1538.
[16] Delpech C, Saliou J, Farnault L, et al. Phytothérapie et chimiothérapie orale, des relations qui ne sont pas sans risques: retour d’expérience au sein d’un service d’hématologie. Le Pharmacien Clinicien 2024; 59: e32-e33.
[17] ALIANE D, CHEBBOUT N, AOUCHAR N, et al. Contribution à l’étude ethnobotanique et l’évaluation de la sécurité des plantes médicinales utilisées par les patients cancéreux dans la wilaya de Tizi-Ouzou. 2021;
[18] Hiermann A, Bucar F. Influence of some traditional medicinal plants of senegal on prostaglandin biosynthesis. Journal of Ethnopharmacology 1994; 42: 111-116.
[19] Kanambaye CODI. Etat de lieu des études phytochimiques menées au Département de Médecine Traditionnelle (DMT) de 2016-2022. USTTB; 2023.
[20] Zeitoun H, El Khoury R, El Beyrouthy M, et al. Phytochemicals screening and anti-tyrosinase activity of Senegalese herbal extracts. synthesis 2016; 5(11): 19781- 19789.
[21] Dharmananda S. The Interaction of Herbs and Drugs. Available from:
[22] Electronic medicines compendium. Amlodipine. Available from:
[23] Vermaak I, Hamman JH, Viljoen AM. High performance thin layer chromatography as a method to authenticate Hoodia gordonii raw material and products. South African Journal of Botany 2010; 76: 119-124.
[24] Colalto C. Herbal interactions on absorption of drugs: Mechanisms of action and clinical risk assessment. Pharmacological Research 2010; 62: 207-227.
Cite This Article
  • APA Style

    Ballo, M., Kassogue, H., Traore, A., Bah, S. (2025). Simultaneous Use of Medicinal Plants and Anticancer and Antihypertensive Drugs in Cancer Patients and Hypertensive Patients: A Case Study from Point G Hospital. Pharmaceutical Science and Technology, 9(2), 72-78. https://doi.org/10.11648/j.pst.20250902.14

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    ACS Style

    Ballo, M.; Kassogue, H.; Traore, A.; Bah, S. Simultaneous Use of Medicinal Plants and Anticancer and Antihypertensive Drugs in Cancer Patients and Hypertensive Patients: A Case Study from Point G Hospital. Pharm. Sci. Technol. 2025, 9(2), 72-78. doi: 10.11648/j.pst.20250902.14

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    AMA Style

    Ballo M, Kassogue H, Traore A, Bah S. Simultaneous Use of Medicinal Plants and Anticancer and Antihypertensive Drugs in Cancer Patients and Hypertensive Patients: A Case Study from Point G Hospital. Pharm Sci Technol. 2025;9(2):72-78. doi: 10.11648/j.pst.20250902.14

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  • @article{10.11648/j.pst.20250902.14,
      author = {Mahamadou Ballo and Hamidou Kassogue and Abdoulaye Traore and Sekou Bah},
      title = {Simultaneous Use of Medicinal Plants and Anticancer and Antihypertensive Drugs in Cancer Patients and Hypertensive Patients: A Case Study from Point G Hospital
    },
      journal = {Pharmaceutical Science and Technology},
      volume = {9},
      number = {2},
      pages = {72-78},
      doi = {10.11648/j.pst.20250902.14},
      url = {https://doi.org/10.11648/j.pst.20250902.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20250902.14},
      abstract = {Cancer and hypertension are two of the leading causes of death worldwide. Earlier detection, treatment and better monitoring ensure effective management. The objective was to study the prevalence and identify the medicinal plants consumed by patients with cancer and high blood pressure. We conducted a descriptive cross-sectional study on the use of medicinal plants by patients undergoing chemotherapy and patients taking antihypertensive drugs, monitored respectively in the medical hematology-oncology department and the cardiology department of the Point-G University Hospital. The prevalence of medicinal plant use was 41.7% (n = 79) among patients undergoing chemotherapy and 59.2% (n = 61) among patients taking antihypertensive medication. Among these patients, women accounted for more than 62% in both cases. The main sources of information on the use of plants were traditional healers, followed by parents. A total of 37 plants species belonging to 22 families were recorded. The Fabaceae family was the most represented, followed by the Combretaceae family. The three most commonly used plants were Guiera senegalensis, Combretum micranthum and Saba senegalensis in patients undergoing chemotherapy and used in combination with carboplatin and ondansetron. Those of patients taking antihypertensive drugs were Euphorbia hirta, Combretum micranthum and Moringa oleifera, used in combination with Amlodipine, Furosemide and Bisoprolol. The risk of side effects was twice as high (relative risk = 2.07) in patients taking antihypertensive drugs who also consumed plants. The study revealed a high prevalence of medicinal plant use. There is a link between the occurrence of adverse effects and plant use.
    },
     year = {2025}
    }
    

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  • TY  - JOUR
    T1  - Simultaneous Use of Medicinal Plants and Anticancer and Antihypertensive Drugs in Cancer Patients and Hypertensive Patients: A Case Study from Point G Hospital
    
    AU  - Mahamadou Ballo
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    AU  - Sekou Bah
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    PB  - Science Publishing Group
    SN  - 2640-4540
    UR  - https://doi.org/10.11648/j.pst.20250902.14
    AB  - Cancer and hypertension are two of the leading causes of death worldwide. Earlier detection, treatment and better monitoring ensure effective management. The objective was to study the prevalence and identify the medicinal plants consumed by patients with cancer and high blood pressure. We conducted a descriptive cross-sectional study on the use of medicinal plants by patients undergoing chemotherapy and patients taking antihypertensive drugs, monitored respectively in the medical hematology-oncology department and the cardiology department of the Point-G University Hospital. The prevalence of medicinal plant use was 41.7% (n = 79) among patients undergoing chemotherapy and 59.2% (n = 61) among patients taking antihypertensive medication. Among these patients, women accounted for more than 62% in both cases. The main sources of information on the use of plants were traditional healers, followed by parents. A total of 37 plants species belonging to 22 families were recorded. The Fabaceae family was the most represented, followed by the Combretaceae family. The three most commonly used plants were Guiera senegalensis, Combretum micranthum and Saba senegalensis in patients undergoing chemotherapy and used in combination with carboplatin and ondansetron. Those of patients taking antihypertensive drugs were Euphorbia hirta, Combretum micranthum and Moringa oleifera, used in combination with Amlodipine, Furosemide and Bisoprolol. The risk of side effects was twice as high (relative risk = 2.07) in patients taking antihypertensive drugs who also consumed plants. The study revealed a high prevalence of medicinal plant use. There is a link between the occurrence of adverse effects and plant use.
    
    VL  - 9
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Author Information
  • Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali

  • Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali

  • Center Hospital of Point-G, Hospital Pharmacy University, Bamako, Mali

  • Center Hospital of Point-G, Hospital Pharmacy University, Bamako, Mali

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