The Role of PTPN22 in Rehumatiode Arthritis and Type 1 Diabeties a Non-MHC Complex Linked
Fawad Akthar,
Muhammad Zeeshan,
Sajid Ali,
Faisal Nouroz,
Sara Khan,
Fazal Jalil,
Uswa Sajid,
Hira Ikram,
Faheem Anwar
Issue:
Volume 5, Issue 3, September 2020
Pages:
29-36
Received:
30 September 2019
Accepted:
30 June 2020
Published:
30 October 2020
Abstract: Rheumatoid Arthritis and Type One Diabetes are devastating clinical conditions characterized by the Autoantibody production against self, affecting up to 5% of population which, ultimately leads to a destruction of cartilage, bones and, insulin; producing Beta cells of Pancreas. As both environmental and genetic factors contribute to these conditions (50-60%). The focus of our review is to enlist that either combined evidence shows the association of Protein Tyrosine Phosphatase Non-receptor type 22 C1858T Polymorphism with these two devastating conditions are not. A minor but most prominent allele of Protein Tyrosine Phosphatase Non-receptor type 22 gene, W620, plays a crucial role in the disease initiation process. The web sources we use for data collection were Google Scholar, PubMed, Online Mendelian Inheritance in Man, and Science Direct. At the same time, the Mesh term of our search was the role of Protein Tyrosine Phosphatase Non-receptor type 22 gene, Single Nucleotide Polymorphism C1858T, 620W, Arg620Trp in Rheumatoid Arthritis and Type One Diabetes. The data set was consist of 210 research articles, which reviewed critically; 73 highly related articles were selected for data extraction to give knowledge to the reader at a glance. Also, taking into account the futuristic perspective for researchers that need further evaluation and will ultimately lead to drug development that will aid enhancement in therapeutics.
Abstract: Rheumatoid Arthritis and Type One Diabetes are devastating clinical conditions characterized by the Autoantibody production against self, affecting up to 5% of population which, ultimately leads to a destruction of cartilage, bones and, insulin; producing Beta cells of Pancreas. As both environmental and genetic factors contribute to these conditio...
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Evaluation of Orange Flesh Sweet Potato Varieties (Ipomoea batatas L.) in West Hararghe Zone of Oromia Region, Eastern Ethiopia
Gezahegn Assefa,
Sintayehu Girma,
Dereje Deresa
Issue:
Volume 5, Issue 3, September 2020
Pages:
37-43
Received:
4 April 2020
Accepted:
22 April 2020
Published:
30 October 2020
Abstract: Sweet potato is an important food security root crop in west Hararghe. it is mainly important for pregnant women and children particularly the Orange fleshed type, which produces storage-carotene, roots precursor of rich in Vitamin A. Therefore, Orange fleshed sweet potato is a promising variety to address the Vitamin A deficiency needs of women and children and to prevent malnutrition in study areas. This experiment was undertaken at Daro labu and Habro districts during 2016-2017 cropping season. The objective of the research was to identify high yielding, adaptable and disease tolerant variety to the study area. A total of three improved Orange fleshed sweet potato varieties; Beletech, Kulfo, Tulla and one local check were used as experimental materials. The experiment was arranged in a Randomized Complete Block Design (RCBD) with three replications. The analysis of variance revealed that there was a significant difference (p<0.05) among the varieties for growth, yield and yield related trait. The highest mean value of marketable root yield was recorded from Kulfo variety with (15.2 ton ha-1) and 0.55 ton yield advantage than a local check. During the experimental period, there was low rainfall distribution in west Hararghe, particularly in the study site. Within the existing moisture stress, Kulfo variety was performed well and gave higher root yielder than improved and local check at both locations. In addition to this, the stability analysis result shows that variety Kulfo was the most stable variety across the two sites. Likewise, the yield and yield contributing parameters and stability analysis over location are important selection parameters which can serve as indicators of adaptability of the sweet potato to the study area and can also be utilized for improving in root yield of sweet potato. Therefore, Kulfo variety was selected as high yield in, adaptable and stress tolerant variety under the rainfed condition at Daro labu and Habro districts of West Hararghe.
Abstract: Sweet potato is an important food security root crop in west Hararghe. it is mainly important for pregnant women and children particularly the Orange fleshed type, which produces storage-carotene, roots precursor of rich in Vitamin A. Therefore, Orange fleshed sweet potato is a promising variety to address the Vitamin A deficiency needs of women an...
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