Modulatory Effect of Ascorbic Acid on Propofol-Induced Anaesthesia in Goats
Veronica Inyamu Ochigbo,
Joseph Olusegun Ayo,
Tagang Aluwong
Issue:
Volume 5, Issue 3, May 2017
Pages:
19-23
Received:
15 May 2017
Accepted:
24 May 2017
Published:
17 July 2017
Abstract: Ascorbic acid modulates the central nervous system either physiologically or pharmacologically, and has been proposed to function as a neuromodulator. The effect of ascorbic acid (AA, vitamin C) on some physiological parameters, onset and duration of anaesthesia following propofol anaesthesia was evaluated in goats. A total of 24 goats divided into four groups, comprising five goats each in groups I and II, and seven goats each in groups III and IV were used for the experiment. Groups I and II served as control for AA (200 mg/kg) and propofol (5 mg/kg) intravenous treatments, respectively; while groups III and IV received AA at 200 mg/kg and 300 mg/kg, respectively before propofol anaesthesia. The result showed that AA significantly (P < 0.05) decreased the onset of anaesthesia and increased the duration of propofol anaesthesia in goats. AA (300 mg/kg) induced a decrease (P < 0.05) in respiratory rate during anaesthesia, but there were no significant changes in heart rate and rectal temperature in the groups. In conclusion, AA potentiated the effect of propofol – induced anaesthesia in goats without alteration in heart rate and rectal temperature.
Abstract: Ascorbic acid modulates the central nervous system either physiologically or pharmacologically, and has been proposed to function as a neuromodulator. The effect of ascorbic acid (AA, vitamin C) on some physiological parameters, onset and duration of anaesthesia following propofol anaesthesia was evaluated in goats. A total of 24 goats divided into...
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Predicting the Ventilatory Support Necessity for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients Using Rapid Shallow Breathing Index
Mohamed Megahed,
Tamer Habib,
Eman Dwidar,
Islam Ahmed
Issue:
Volume 5, Issue 3, May 2017
Pages:
24-28
Received:
23 June 2017
Accepted:
26 July 2017
Published:
24 October 2017
Abstract: Acute exacerbation of chronic obstructive pulmonary disease (COPD) is a common cause of intensive care unit (ICU) admission due to respiratory failure which often necessitates mechanical ventilation (MV). This study evaluated the rapid shallow breathing index (RSBI) as a predicator of ventilatory support necessity in patients admitted with acute exacerbation of COPD. This study was conducted on 100 acute COPD exacerbation patients who admitted to the critical care department at Alexandria main university hospital. All enrolled patients (n=80) were subjected on admission to RSBI measurement on admission and every 30 minutes for the first 2 hours. The RSBI cutoff value that discriminated best between the need for noninvasive and invasive MV using the Receiver Operating Characteristic (ROC) was > 241 breath/minute/Liter, it showed a sensitivity of 88.33% and a specificity of 100%. RSBI may be a good predictor of ventilatory support necessity in acute exacerbation of COPD.
Abstract: Acute exacerbation of chronic obstructive pulmonary disease (COPD) is a common cause of intensive care unit (ICU) admission due to respiratory failure which often necessitates mechanical ventilation (MV). This study evaluated the rapid shallow breathing index (RSBI) as a predicator of ventilatory support necessity in patients admitted with acute ex...
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