Research Article
Low-Grade Ameloblastic Fibrosarcoma of the Mandible: A Case Report with Initial Misdiagnosis
Issue:
Volume 11, Issue 2, December 2025
Pages:
58-62
Received:
30 June 2025
Accepted:
7 July 2025
Published:
24 July 2025
Abstract: Background: Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor characterized by benign epithelial components and a malignant mesenchymal stroma. Accurate diagnosis is challenging, especially when initial biopsy samples are limited. Case Presentation: A 35-year-old male presented with a progressively enlarging swelling on the left side of his face. Clinical examination revealed a firm, non-tender mass in the left mandibular region, resulting in mild facial asymmetry. Intraoral evaluation showed buccal cortical expansion in the posterior mandible, accompanied by slight mobility of the adjacent teeth. Panoramic radiograph and cone beam computed tomography (CBCT) revealed an ill-defined, multilocular radiolucent lesion involving the left mandibular body and ramus, with cortical bone perforation and mild soft tissue extension. An incisional biopsy initially diagnosed ameloblastic fibroma (AF). The patient underwent segmental mandibulectomy, and final histopathological evaluation revealed low-grade ameloblastic fibrosarcoma. Reconstruction was performed using a reconstruction plate and autogenous iliac bone graft. The postoperative course was uneventful, with no recurrence observed during a 6-month follow-up. Conclusions: This case underscores the diagnostic challenges of AFS and highlights the importance of comprehensive histopathological evaluation. Early detection, accurate diagnosis, and complete surgical excision with clear margins are critical for best outcomes.
Abstract: Background: Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic tumor characterized by benign epithelial components and a malignant mesenchymal stroma. Accurate diagnosis is challenging, especially when initial biopsy samples are limited. Case Presentation: A 35-year-old male presented with a progressively enlarging swelling on the left...
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Case Report
Mandibular Langerhans Cell Histiocytosis in Pediatric and Geriatric Patients: Report of Two Cases with Contrasting Clinical Features
Issue:
Volume 11, Issue 2, December 2025
Pages:
63-68
Received:
20 September 2025
Accepted:
4 October 2025
Published:
28 October 2025
DOI:
10.11648/j.ijcoms.20251102.12
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Abstract: Langerhans Cell Histiocytosis (LCH) is a rare clonal proliferative disorder of dendritic cells that most commonly affects children but may also present in adults and elderly patients. When the mandible is involved, its clinical and radiographic appearance often mimics a variety of benign or malignant jaw lesions, posing significant diagnostic challenges for dental and medical practitioners. In this report, we describe two illustrative cases of mandibular LCH occurring at opposite ends of the age spectrum. The first case involved a 3-year-old girl who presented with a painless swelling in the anterior mandible. Radiographic examination revealed a poorly defined radiolucent lesion, and histopathological analysis with molecular testing confirmed LCH harboring the BRAF V600E mutation. The patient received targeted therapy with Vemurafenib, resulting in substantial clinical improvement and sustained remission during follow-up. The second case concerned a 65-year-old male who presented with persistent mandibular pain, lower-lip paresthesia, and an intraoral ulcer. Imaging demonstrated multiple bilateral punched-out radiolucencies in the mandible. Histopathological and immunohistochemical studies confirmed the diagnosis of LCH. The patient underwent surgical segmental resection of the affected mandible with subsequent reconstruction using a titanium plate, leading to satisfactory healing and no evidence of recurrence on follow-up. These contrasting cases emphasize the importance of considering LCH in the differential diagnosis of mandibular lesions across all age groups. Prompt imaging, biopsy, molecular testing, and multidisciplinary management are crucial for accurate diagnosis and effective treatment strategies that improve patient outcomes.
Abstract: Langerhans Cell Histiocytosis (LCH) is a rare clonal proliferative disorder of dendritic cells that most commonly affects children but may also present in adults and elderly patients. When the mandible is involved, its clinical and radiographic appearance often mimics a variety of benign or malignant jaw lesions, posing significant diagnostic chall...
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,
Samira Mostafazadhe
