Verification of “Dissolution” Test for Famotidine Tablets with UV-spectrophotometric Determination
Artem Myhal,
Olga Golovchenko,
Svitlana Gubar,
Victoriya Georgiyants
Issue:
Volume 1, Issue 1, June 2017
Pages:
6-9
Received:
31 October 2016
Accepted:
6 December 2016
Published:
5 January 2017
DOI:
10.11648/j.pst.20170101.13
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Abstract: Famotidine is a new generation of antiulcer drugs. There are 14 different dosage forms are registered in Ukraine, and 50% of them are produced by Ukrainian pharmaceutical factories. That is why it is necessary to include into the first supplement of the second edition of the State Pharmacopeia of Ukraine monographs for regulating quality control of dosage forms with famotidine. Methods of quality control for famotidine tablets are present in the United States Pharmacopeia, and do not require complete validation procedure, but only their verification. The USP method for “Dissolution” test for famotidine tablets with UV-spectrophotometry determination was verified for including to the State Pharmacopeia of Ukraine. Specificity, linearity, convergence, as well as the accuracy were determined for this method and confirmed its correctness. The total uncertainty of the method is 1.12% that not more than critical value of total uncertainty for the “Dissolution” test (3.00%).
Abstract: Famotidine is a new generation of antiulcer drugs. There are 14 different dosage forms are registered in Ukraine, and 50% of them are produced by Ukrainian pharmaceutical factories. That is why it is necessary to include into the first supplement of the second edition of the State Pharmacopeia of Ukraine monographs for regulating quality control of...
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The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers
Issue:
Volume 1, Issue 1, June 2017
Pages:
10-12
Received:
11 October 2016
Accepted:
9 February 2017
Published:
1 March 2017
DOI:
10.11648/j.pst.20170101.14
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Abstract: On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.
Abstract: On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,...
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