Prostate cancer (PCa) is a common and severe disease that affects many men worldwide. We need new strategies to prevent and treat PCa more effectively. This research project focuses on the relationship between obesity-associated inflammation and PCa, aiming to develop innovative prevention and personalized treatment approaches.

The study has two main goals: firstly, to identify the factors and genes involved in the progression of PCa. Understanding these factors and genes can help us develop new treatments for PCa.The second goal is to understand how obesity-related factors contribute to the development of PCa and interact with periprostatic microenvironment PPAT. We will conduct experiments using cancer cells and tissue samples to study the effects of these factors. Patients about their medication use, body measurements, and lab test results will be analyzed.

We will conduct laboratory experiments using cancer cells and patient samples to achieve these goals. We will manipulate the expression of genes and factors associated with obesity to study their effects on PCa. In parallel, we will collect data from a group of patients in Hong Kong, including their medical history, body measurements, and lab test results.

By identifying the key factors and genes involved in PCa progression, we can develop targeted treatments tailored to individual patients. The screening model we develop will help primary care doctors identify individuals at higher risk of PCa, allowing for timely interventions and better outcomes.

The findings of this study will be shared through international conferences and high-impact journals, contributing to the global understanding of PCa. Ultimately, this research aims to improve the lives of PCa patients by developing innovative strategies for prevention and personalized treatment. With your support, we can make a real difference in the fight against PCa and reduce the burden of this disease on individuals and society.