Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode
Jayant Ira Gowda,
Rohini Manohar Hanabaratti,
Sharanappa Thotappa Nandibewoor
Issue:
Volume 7, Issue 5, September 2019
Pages:
92-97
Received:
1 July 2019
Accepted:
12 August 2019
Published:
25 November 2019
Abstract: Tripelennamine hydrochloride (TPA) primarily acts as first generation antihistamine psychoactive or H1 receptor antagonist and an antipruritic drug. In the present study, the voltammetric behavior of TPA was studied using glassy carbon electrode with pH ranging from 4.2 to 10.4. Cyclic voltammetry (CV) and Differential pulse voltammetric (DPV) techniques have beenemployed in order to elucidate an irreversible electrodic reaction with maximum anodic peak current at pH 7.0. Surface area of the electrode was calculated and was found to be 0.0202 cm2. Scan rate variation shows that electrodic reaction involves electron transfer with diffusion controlled mass transfer process. The heterogeneous electron transfer rate constant (k0) was obtained to be 1.332× 103 s-1. A linear relationship between peak current and TPA concentrations was obtained from 0.9×10-7 M to 10.0 × 10-5 M by using DPV and limit of detection of 9.7 × 10-8 M was estimated. In addition, a sensitive voltammetric method was developed, and it was successfully applied for TPA determination in pharmaceutical sample and human urine samples.The present method was also applied for the determination of TPA in pharmaceutical samples, with satisfactory recoveries from 95.32 % to 100.12 %.
Abstract: Tripelennamine hydrochloride (TPA) primarily acts as first generation antihistamine psychoactive or H1 receptor antagonist and an antipruritic drug. In the present study, the voltammetric behavior of TPA was studied using glassy carbon electrode with pH ranging from 4.2 to 10.4. Cyclic voltammetry (CV) and Differential pulse voltammetric (DPV) tech...
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