Metal Complexes as Potential Antimicrobial Agent: A Review
Md. Saddam Hossain,
C. M. Zakaria,
Md. Kudrat-E-Zahan
Issue:
Volume 4, Issue 1, March 2018
Pages:
1-21
Received:
11 July 2017
Accepted:
8 August 2017
Published:
8 January 2018
Abstract: Metal ions play many critical functions in humans. Deficiency of some metal ions can lead to disease like pernicious anemia resulting from iron deficiency, growth retardation arising from insufficient dietary zinc, and heart disease in infants owing to copper deficiency. Antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically day by day. In this sense there is a strong need to synthesis new substances that not only have good spectrum of activity, but having new mechanisms of action. Inorganic compounds particularly metal complexes have played an important role in the development of new metal based drugs. A significantly rising interest in the design of metal complexes as drugs and diagnostic agents is currently observed in the area of scientific inquiry, specifically termed medicinal inorganic chemistry. In this review our main focused on research undertaken over the past few decades which has sought to possess preclinical pharmacological screenings like anti-bacterial, anti-fungal, anti-inflammatory, anti-cancer, DNA- interaction and anti-tumor action of synthetic metal complexes.
Abstract: Metal ions play many critical functions in humans. Deficiency of some metal ions can lead to disease like pernicious anemia resulting from iron deficiency, growth retardation arising from insufficient dietary zinc, and heart disease in infants owing to copper deficiency. Antibiotic resistance has been growing at an alarming rate and consequently th...
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Synthesis and Properties of Macrocyclic Complexes Ruthenium Azerbaijan State University of Oil and Industry
Mikayilova Mexriban Rahil,
Mustafayeva Rena Eldar
Issue:
Volume 4, Issue 1, March 2018
Pages:
22-25
Received:
18 October 2017
Accepted:
23 November 2017
Published:
29 January 2018
Abstract: Synthetic methods have been developed and Ru (IV) complex compounds with five types of donor ligands have been prepared: phenanthroline, nicotinic acid amide, imidazole, benzimidazole and their derivatives, and phthalocyanine. New method for the synthesis of rhenium and ruthenium phthalocyanines is proposed, which is distinguished by its availability and high yields. It is established that because of synthesis only one form of ruthenium phthalocyanine is formed, which can be attributed to the PcRuO structure based on physical and chemical studies.
Abstract: Synthetic methods have been developed and Ru (IV) complex compounds with five types of donor ligands have been prepared: phenanthroline, nicotinic acid amide, imidazole, benzimidazole and their derivatives, and phthalocyanine. New method for the synthesis of rhenium and ruthenium phthalocyanines is proposed, which is distinguished by its availabili...
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Synthesis of Pyridine and Phenyl Succinimides by Green Pathway and Their Antimicrobial Assay
Ravindra Dhivare,
Prashant Chaudhari,
Shankarsing Rajput
Issue:
Volume 4, Issue 1, March 2018
Pages:
26-29
Received:
15 November 2017
Accepted:
6 December 2017
Published:
30 January 2018
Abstract: A simple and clean green method was implemented for the preparation of different succinimide derivatives by means of the N-substituted anilines or N-substituted 2-aminopyridines with succinic anhydride with the heating in aqueous medium. The total synthesized 3a-j compounds were evaluated against antibacterial and antifungal species.
