Green Protocol for the Synthesis of Catalyst Free Biginelli Products
Abdul Ghafoor,
Naved Sajid,
Muhammad Adnan,
Muhammad Naeem Khan,
Amin Abid,
Ansa Madeeha Zafar,
Muhammad Ahmad,
Noreen Aslam,
Mussarat Jabeen,
Amjad Ali,
Misbahul Ain Khan
Issue:
Volume 6, Issue 1, June 2020
Pages:
1-5
Received:
5 September 2019
Accepted:
26 April 2020
Published:
28 May 2020
Abstract: Applications of multicomponent reactions (MCRs) in the preparation of diverse types of heterocyclic compounds carries a unique place in chemical synthesis. Biginelli reaction, among the loop of multicomponent reactions, provide an efficient way to access of highly functionalized dihydropyrimidones (-thiones) (DHPMs). In the current study, we employed multicomponent Biginelli reaction to synthesis range of different dihydropyrimidones (-thiones) derivatives in variable yields. A solvent-free eco-friendly green protocol without any expensive catalyst has been optimized and expand to synthesize series of DHMPS in 34 to 72% yield. The optimized method proved to be successful with various types of different aromatic aldehydes, 1, 3-dicarbonyl compounds and urea (thiourea) under solvent and catalyst free condition to access dihydropyrimidones (thiones). Different spectroscopic techniques include NMR, FTIR etc. have used to confirm the structures of compounds. Further exploration of Biginelli reaction to prepare DHPMs and related compounds is under way in the lab and will be published in due course.
Abstract: Applications of multicomponent reactions (MCRs) in the preparation of diverse types of heterocyclic compounds carries a unique place in chemical synthesis. Biginelli reaction, among the loop of multicomponent reactions, provide an efficient way to access of highly functionalized dihydropyrimidones (-thiones) (DHPMs). In the current study, we employ...
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Overview of Recent Advances in 3-Hydroxycoumarin Chemistry as a Bioactive Heterocyclic Compound
Issue:
Volume 6, Issue 1, June 2020
Pages:
6-15
Received:
16 July 2020
Accepted:
30 July 2020
Published:
18 August 2020
Abstract: Coumarins or benzo-2-pyrone derivatives are one of the most significant families of natural compounds and are also important in synthetic organic chemistry. They have been widely used as starting materials or precursor molecules in the pharmaceutical, perfumery and agrochemical industries, etc. Hydroxycoumarins are an important class of coumarin compounds that possess several physical, chemical and biological properties. Among the hydroxycoumarins, 3-hydroxycoumarin seems to be the most important because of its numerous chemical, photochemical and biological properties. However, this compound remains less well known compared to others of the same class such as 7-hydroxycoumarin and 4-hydroxycoumarin. This study is therefore devoted to 3-hydroxycoumarin and its applications. The main purpose of this review is to summarize and document the recent advances on 3-hydroxycoumarin, concerning the main routes of its synthesis, its reactivity, its applications in different fields of biology. Several methods for the synthesis of 3-hydroxycoumarin have been described in the literature, most of which use salicylic aldehyde and 1-(2-hydroxyphenyl)ethanone as starting compounds. Other synthesis pathways exist, but they are based on intermediate synthesis compounds. Concerning the reactivity of 3-hydroxycoumarin, many heterocyclic compounds obtained from 3-hydroxycoumarin have been reported in the literature. Among these heterocycles are pyrido[2,3-c]coumarin derivatives, chromeno[4,3-e][1,3]oxazine derivatives, dihydropyrano[2,3-c] chromenes and 3-coumarinyl carboxylates. Various researches have also concerned the biological properties of this compound. It appears from these numerous studies that 3-hdroxycoumarin is used in fields such as genetics, pharmacology, microbiology, etc.
Abstract: Coumarins or benzo-2-pyrone derivatives are one of the most significant families of natural compounds and are also important in synthetic organic chemistry. They have been widely used as starting materials or precursor molecules in the pharmaceutical, perfumery and agrochemical industries, etc. Hydroxycoumarins are an important class of coumarin co...
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