Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model
Sahar Mohamed Kamal Shams El Dine
Issue:
Volume 2, Issue 4, July 2014
Pages:
50-55
Received:
9 August 2014
Accepted:
23 August 2014
Published:
10 September 2014
Abstract: The present study is designed to investigate the possible hepatotoxic effects of the anti-epileptic drug “lamotrigine, LTG” in adult male wister rats after picrotoxin –induced convulsions and exposure for 21 days to chronic restraint model. This was done by a trial to find out alterations in the activities of liver enzymes and some antioxidants in this model of co-morbidity. They were treated by gastric gavage with LTG [20mg/kg body wt.] for 21days. Then rats were anesthetized and dissected to remove liver and to collect blood. Selected liver enzymes [AST, ALT] and some anti-oxidant enzymes were assayed. The results indicated that the drug significantly increased the activities of glutathione peroxidase and catalase enzymes in hepatic homogenates, while it significantly decreased the level of the lipid peroxidation expressed as thiobarbituric acid-reactive substance (TBARS) in these homogenates. However, there was an elevation of tested liver enzymes ALT & AST at the end of 21 days. This revealed the occurrence of possible hepatocellular damage. The present study recommends a regular liver function and drug monitoring during the therapeutic use of this drug in epilepsy-stress co-morbidity.
Abstract: The present study is designed to investigate the possible hepatotoxic effects of the anti-epileptic drug “lamotrigine, LTG” in adult male wister rats after picrotoxin –induced convulsions and exposure for 21 days to chronic restraint model. This was done by a trial to find out alterations in the activities of liver enzymes and some antioxidants in ...
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Intracranial Aspergillosis Mimicking a Middle Cranial Fossa Tumor Involving the Cavernous Sinus in an Immunocompetent Patient: Case Report and Literature Review
Mohamed Badri,
Bouali Sofiene,
Boubaker Adnene,
Bahri Kamel,
Jemel Hafedh,
Zammel Ihsen
Issue:
Volume 2, Issue 4, July 2014
Pages:
56-59
Received:
1 September 2014
Accepted:
11 September 2014
Published:
20 September 2014
Abstract: Intracranial aspergillosis is rare in immunocompetent patients. Extension to the cranial base via the sphenoid sinus is exceptional. Authors report a case of middle cranial fossa aspergillosis involving the cavernous sinus and mimicking an extra-axial tumor in an immunocompetent 65 year-old male. The patient had been suffering from left trigeminal neuralgia and a horizontal diplopia since 4 months. Physical examination featured a left complete ophtalmoplegia and an hyperesthesia of the left maxillary nerve. Radiological examination showed a left temporal extra-axial temporal expanding intracranial lesion, involving the left cavernous sinus with extension to the sphenoidal sinus. A large tumor resection was performed through a left fronto-temporal craniotomy with no postoperative complications. Pathologic examination and specimen culture concluted to an Aspergillus fumigatus. Authors discuss the clinical, radiological features and management of such lesion through a literature review.
Abstract: Intracranial aspergillosis is rare in immunocompetent patients. Extension to the cranial base via the sphenoid sinus is exceptional. Authors report a case of middle cranial fossa aspergillosis involving the cavernous sinus and mimicking an extra-axial tumor in an immunocompetent 65 year-old male. The patient had been suffering from left trigeminal ...
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